O-glycosylation of nuclear and cytoplasmic proteins by a single β-N-acetyl-D-glucosamine moiety (O-GlcNAc) is a common post-translational modification that ishighly dynamic and fluctuates in response to cellularstimuli. Many of the first proteins identified carrying this modification were transcription factors, and it has become clear in the last several years that O-GlcNAc plays a major role in chromatin remodeling and gene expression. GlycoScientific has developed a novel immunization strategy to develop site specific antibodies that detect O-GlcNAc modified epitopes. We have used this novel approach to develop a variety of antibodies to histone targets.
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