Guinea Pig Reagents
Guinea pig (Cavia porcellus) are commonly recognized as one of the earliest used laboratory research animals. They share many similarities in biology and disease state progression with humans, making them ideal candidates for studying human illnesses. Research using Guinea Pigs has led to many important discoveries from Vitamin C to the bacteria Mycobacterium tuberculosis as the causative agent of tuberculosis. Study of diseases such as tuberculosis in Guinea Pig models has often relied on host mortality, bacterial loads, and qualitative assessment of pathology at necropsy. These are blunt tools, largely unrelated to the markers used for diagnosis and epidemiological studies of human tuberculosis. The lack of immunological reagents for Guinea Pigs has thus far hampered efforts to study disease states through relevant biomarkers. GlycoScientific has developed a range of antibodies against Guinea Pig cytokines and immunological markers such as STAT and JAK to fulfill this unmet need.
Guinea Pig Reagents
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Tumor Necrosis Factor alpha
Discover our collection of Cavia porcellus TNFa proteins and antibodies.The cytokine tumor necrosis factor alpha exists as both a transmembrane form and a soluble form and is mainly found on monocytes and macrophages. TNFa interacts with other cytokines such as IL-1 and IL-6 to mediate other immune cells and to function as an endogenous pyrogen.
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Interleukin 1 alpha
Discover our collection of Cavia porcellus IL1a proteins and antibodies.IL1a is a proinflammatory cytokine that binds to theIL-1R1 receptor to mediate activation of myriad downstream immune cytokines and immune mediators.
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Interleukin 2
Discover our collection of Cavia porcellus IL2 proteins and antibodies.The cytokine Interleukin 2 plays a vital role in the immune system. Interleukin 2 promotes activation and differentiation of T cells and helps regulate immune response and prevent autoimmunity.
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Interleukin 4
Discover our collection of Cavia porcellus IL4 proteins and antibodies.The cytokine Interleukin 4 plays a vital role in adaptive and humoral immunity by activating B and T cell proliferation. IL4 facilitates B cell differentiation and class switching to IgE.
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Interleukin 6
Discover our collection of Cavia porcellus IL6 proteins and antibodies.The macrophage produced cytokine Interleukin 6 plays a key role in acute pro-inflammatory immune response.
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Interleukin 8
Discover our collection of Cavia porcellus IL8 proteins and antibodies.Interleukin (IL)-8/CXCL8 is a is a pro-inflammatory chemokine produced by a variety of cell types that triggers neutrophil activation and migration.
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Interleukin 17A
Discover our collection of Cavia porcellus IL17 proteins and antibodies.Interleukin 17A is a member of the cytokine family of IL17s that include subsets A-F. It is essential to helper T17 cell function and induces production of a variety of cytokines, chemokines, and prostoglandins.
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Interleukin 23
Discover our collection of Cavia porcellus IL23 proteins and antibodies.Mature IL23 is a heterodimeric protein consisting of the IL23a (p19) subunit and the IL12b (p40) subunit. This proinflammatory cytokine is expressed by activated macrophages and dendritic cells.
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JAK/STAT
Discover our collection of Cavia porcellus JAK/STAT peptides and antibodies.An important immune system pathway is that of the tyrosine kinases JAK (Janus Kinase) and signal transducer and activator of transcription (STATs). Understanding the phosphorylation state leading to immune system activation via this pathway is vital to progressing research on a variety of diseases. GlycoScientific has developed a variety of antibodies to STAT and Jak.