IgG Isotope and Glycoprotein Quantitation Standards
The use of internal standards is the accepted strategy to facilitate quantitation via MS. The closer the chemical properties of the internal standard to its analyte, the better it compensates for the various sources of error, and thus the most desirable internal standard is typically an isotopically labeled version of the analyte itself. Consequently, the optimal internal standard for a glycoprotein is a labeled glycoprotein. This led GlycoScientific to develop monoclonal antibodies with a range of labeled moieties, which can be added directly to the sample prior to processing and thus overcoming systematic errors associated with parallel sample handling.
C o n t r o l I n n o v a t e S t a n d a r d i z e
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IgG Isotope and Glycoprotein Quantitation Standards
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IgG1
Learn more about IgG1 standardsGlycoScientific has developed a wide array of isotopically labeled IgG1 monoclonals. Explore our wide array of internal standard for quantifying IgG1 antibodies, Fc-fusion proteins with an IgG1 Fc, and their glycans.
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iGlycoMab
Learn More about iGlycoMabiGlycoMab is a highly purified murine IgG2b monoclonal antibody whose glycans are labeled with the stable isotope (15N).
iGlycoMab was developed to be used as an internal standard for the quantitation of glycoprotein glycans.
Did you know?
We also offer a recombinant Erythropoietin. Epo's diverse and complex glycosylation profile make it the perfect tool for in-depth glycan characterization.
Publications
Zhou S, Tello N, Harvey A, Boyes B, Orlando R, Mechref Y. Electrophoresis. 2016 Jun;37(11):1489-97. doi: 10.1002/elps.201600013. Epub 2016 Apr 9. PMID: 26913967; PMCID: PMC4964797.
Publications
Nath, N., Godat, B., Flemming, R. et al. Sci Rep 12, 12185 (2022). https://doi.org/10.1038/s41598-022-15887-z
Nath N, Godat B, Flemming R, Urh M. J Immunol. 2021 Aug 15;207(4):1211-1221. doi: 10.4049/jimmunol.2100181. Epub 2021 Jul 26. PMID: 34312257; PMCID: PMC8358922.
Misra SK, Orlando R, Weinberger SR, Sharp JS. AAPS J. 2019 Jul 11;21(5):87. doi: 10.1208/s12248-019-0358-2. PMID: 31297623; PMCID: PMC7670911.
Tadi S, Misra SK, Sharp JS. Anal Chem. 2021 Feb 23;93(7):3510-3516. doi: 10.1021/acs.analchem.0c04872. Epub 2021 Feb 9. PMID: 33560821; PMCID: PMC7951798.