IgG4 UmAb4

IgG4 antibodies differ from the more widely studied and naturally abundant IgG1 antibodies.  In addition to having a shorter hinge region and differences in disulfide bond placement, IgG4s have reduced effector function.  The unique role that IgG4s play in immune function make them ideal for certain therapeutic purposes.  GlycoScientific offers a human monoclonal IgG4 kappa antibody purified from protein free CHO culture.

Product Details:

Biosimilar: Natalizumab 

Source: CHO

Clone: Monoclonal

Isotype: Human IgG4, kappa

Target: alpha4-integrin

Known Species Reactivity: Human

Form: Dried down from PBS

Assay: ≥95% (SDS-PAGE)

Label: None

Tested Applications: MS

Light Chain

DIQMTQSPSS LSASVGDRVT ITCKTSQDIN KYMAWYQQTP GKAPRLLIHYTSALQPGIPS RFSGSGSGRDYTFTISSLQPEDIATYYCLQ YDNLWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQE SVTEQDSKDS TYSLSSTLTL SKADYEKHKV YACEVTHQGL

SSPVTKSFNRGEC

Heavy Chain

QVQLVQSGAE VKKPGASVKV SCKASGFNIK DTYIHWVRQA PGQRLEWMGR

IDPANGYTKY DPKFQGRVTI TADTSASTAY MELSSLRSED TAVYYCAREG

YYGNYGVYAM DYWGQGTLVT VSSASTKGPS VFPLAPCSRS TSESTAALGC

LVKDYFPEPV TVSWNSGALT SGVHTFPAVL QSSGLYSLSS VVTVPSSSLG

TKTYTCNVDH KPSNTKVDKR VESKYGPPCP SCPAPEFLGG PSVFLFPPKP

KDTLMISRTP EVTCVVVDVS QEDPEVQFNW YVDGVEVHNA KTKPREEQFN

STYRVVSVLT VLHQDWLNGK EYKCKVSNKG LPSSIEKTIS KAKGQPREPQ

VYTLPPSQEE MTKNQVSLTC LVKGFYPSDI AVEWESNGQP ENNYKTTPPV

LDSDGSFFLY SRLTVDKSRW QEGNVFSCSV MHEALHNHYT QKSLSLSLGK

Click here for a sample data sheet.