Recombinant Human IgG Standard Proteins

Immunoglobulin G antibodies are glycoproteins that make up the majority of human serum antibodies and play a major role in the humoral immune response.  IgG antibodies are the most prevalent of the five human classes and can further be divided into four subclasses IgG1, IgG2, IgG3, and IgG4.  Antibodies are comprised of a variable region and a constant region that shares more than 90% sequence homology between these different subclasses.  Despite these similarities each IgG subclass have distinct structural features and roles in immune response.   

The use for antibodies in therapeutics and scientific research continues to grow.  Glycoscientific provides cost effective, quality recombinant antibodies to fit your research needs.  Key features of our IgG Standard Proteins include:

                                     

Recombinant Human IgG1 Standards

Recombinant Human IgG2 Standards

Recombinant Human IgG4 Standards

Publications

Do I Need to Trypsin Digest Before Releasing IgG Glycans With PNGase-F 

Birx L, Popov M, Orlando R. J Biomol Tech. 2023 Mar 1:3fc1f5fe.6db6338a. doi: 10.7171/3fc1f5fe.6db6338a.

A homogeneous bioluminescent immunoassay for parallel characterization of binding between a panel of antibodies and a family of Fcγ receptors.         

Nath, N., Godat, B., Flemming, R. et al. Sci Rep 12, 12185 (2022). https://doi.org/10.1038/s41598-022-15887-z

Deciphering the Interaction between Neonatal Fc Receptor and Antibodies Using a Homogeneous Bioluminescent Immunoassay                                      

Nath N, Godat B, Flemming R, Urh M. J Immunol. 2021 Aug 15;207(4):1211-1221. doi: 10.4049/jimmunol.2100181. Epub 2021 Jul 26. PMID: 34312257; PMCID: PMC8358922.

Compensated Hydroxyl Radical Protein Footprinting Measures Buffer and Excipient Effects on Conformation and Aggregation in an Adalimumab Biosimilar.                                                                                                        

Misra SK, Orlando R, Weinberger SR, Sharp JS. AAPS J. 2019 Jul 11;21(5):87. doi: 10.1208/s12248-019-0358-2. PMID: 31297623; PMCID: PMC7670911.

Inline Liquid Chromatography-Fast Photochemical Oxidation of Proteins Allows for Targeted Structural Analysis of Conformationally Heterogeneous Mixtures.                                                                                                          

Tadi S, Misra SK, Sharp JS. Anal Chem. 2021 Feb 23;93(7):3510-3516. doi: 10.1021/acs.analchem.0c04872. Epub 2021 Feb 9. PMID: 33560821; PMCID: PMC7951798.