Importance of the Guinea Pig to Science
Guinea pig (Cavia porcellus) are commonly recognized as one of the earliest used laboratory research animals. They share many similarities in biology and disease state progression with humans, making them ideal candidates for studying human illnesses. Research using Guinea Pigs has led to many important discoveries from Vitamin C to the bacteria Mycobacterium tuberculosis as the causative agent of tuberculosis. Study of diseases such as tuberculosis in Guinea Pig models has often relied on host mortality, bacterial loads, and qualitative assessment of pathology at necropsy. These are blunt tools, largely unrelated to the markers used for diagnosis and epidemiological studies of human tuberculosis. The lack of immunological reagents for Guinea Pigs has thus far hampered efforts to study disease states through relevant biomarkers. GlycoScientific has developed a range of antibodies against Guinea Pig cytokines and immunological markers such as STAT and JAK to fulfill this unmet need.
Guinea Pig Antibodies
Antibodies are a powerful research tool that can be used in a variety of scientific applications such as ELISA, Western blot, Immunohistochemistry, and flow cytometry. GlycoScientific has developed a unique set of antibodies to Guinea pig target proteins, an area of research that has historically suffered from a lack of reagent options.
Choosing the right tool for your research
Polyclonal Antibodies (pAbs) represent a mixture of antibodies produced by various B cells of different lineages. These antibodies usually recognize a variety of epitopes on the same target protein. Benefits of polyclonal antibodies include:
- Ability to detect low abundance proteins due to multiple epitope binding.
- Ability to detect a protein even when an epitope is hidden due to differential folding, glycosylation, or other modification.
- GlycoScientific's approach of generating Guinea Pig antibodies against full length targets mean that our polyclonal antibodies can capture the full benefit of a multi-epitope specific mixture compared to many commercial polyclonal antibodies that are made against short peptide sequences.
Monoclonal Antibodies (mAbs) represent a single immunological molecule that is capable of binding a single epitope. Monoclonal antibodies are isolated from a single clone and are recombinantly generated in laboratories. Benefits of monoclonal antibodies include:
- High specificity due to single epitope binding.
- Single isotype design for specific immunological effect targeting.
- Reproducibility-the synthetic manufacturing of mAbs ensures consistent results across different lots.
Guinea Pig Monoclonal Antibodies
Guinea Pig Polyclonal Antibodies
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GP STAT pAb
There are seven known Signal transducer and activator of transcription (STAT) factors...